Clinical Research


Skin Healing and Inflammation: This study investigates the effect of light therapy on our cells’ mitochondria. Researchers demonstrated that light therapy causes energy to move more efficiently throughout your b ody which improves physical function, speeds the healing process, and lowers inflammation and pain. [1]

Increased Circulation: Researchers in this study identified an increase in circulation following red light therapy, indicating tissues are receiving mor e oxygen and other nutrients important for healing — while also ridding themselves of toxic byproducts. [2]

Chronic Inflammation: A 2017 study shows that red light therapy alleviates both acute and chronic inflammation by increasing blood flow to the damaged tissues. [3]

Collagen Production: In study after study, researchers have measured much higher natural collagen levels in the models and patients treated with natural light, especially with near infrared light. [4,5,6,7]

Younger Looking Skin: Several human trials and laboratory studies on red light therapy have demonstrated that daily red light treatments help your skin regenerate faster, helping you look younger. A 2017 trial assessed 30 women ages 30 – 55 who used red light therapy. The team concluded that red light therapy “had positive effects on wrinkle and moisture content of adult women’s faces.”. [8,9,10,11]

Red Light Therapy for Eczema & Psoriasis: We’re just beginning to learn about the positive effects light therapy can have on psoriasis. Researcher s cited a recent study that found “no adverse side effects and a resolution of psoriasis” for patients who weren’t helped by traditional treatments. [8]

Red Light for Depigmentation Conditions like Vitiligo: Red light has a strong record of improving re – pigmentation for skin with de – pigmentation conditions like vitiligo. [14] Researchers have shown that light therapy “can increase pigmentation by stimulating melanocyte proliferation and reduce depigmentation by inhibiting autoimmunity.” [8]

An extensive 2013 meta analysis of red light therapy’s effects on skin and concluded:

Red Light Lessens Wrinkles and Signs of Aging: The analysis cited numerous studies showing how light therapy counteracts signs of aging in skin. Red and near infrared light has been sho wn to boost collagen, smooth wrinkles, and enhance skin tone, for an overall younger look. [9]

Red Light Rejuvenates Skin: The researchers noted red light was particularly effective for healing and skin regeneration, as well as reducing inflammation. [9]

Red Light Therapy for Treating Acne: Researchers in 2013 highlighted studies showing red and near infrared light to be effective for the treatment of acne. Of note, they explained that red light impacts sebum production, which contributes to acne, in additi on to the control of cytokines, which impacts skin inflammation. [9]

Weight Loss

Less Cellulite with Red Light Therapy: In a 2011 study on red light therapy and cellulite reduction, women ages 25 – 55 were divided into two groups: some did treadmill exercis e + red light therapy twice a week, while the other group just did treadmill exercise. The researchers presented thermographic photographs of the changes in thigh circumference and cellulite to demonstrate that red light therapy and exercise was more effec tive than just exercise alone. The study concluded that treadmill exercise and red light therapy in conjunction can improve body aesthetics. [10]

Smaller Waistline, Less Girth with Red Light: This 2011 double – blind, randomized study performed light therapy at 635 – 680 nanometers (nm) on participants for four weeks and recorded effects on the size of their waistline. At the end of the study, participants had achieved a statistically significant reduction in waistline girth. [11]

Red Light Therapy for Target ed Fat Loss: In a similar study published in Lasers in Surgery Medicine, participants who received light therapy showed a significant reduction in overall circumference, including numerous parts of the body. Researchers concluded that light therapy can red uce the circumference of the specific areas of the body that are treated with natural light. [12]

Less Body Fat: A 2018 triple – blind, placebo – controlled trial assessed red light therapy’s effects on people doing endurance training. Researchers found pre – ex ercise treatment can “decrease the body fat in healthy volunteers when compared to placebo.” [13]

Weight and Obesity Control: A study conducted by Brazilian researchers in 2015 assessed the effects of light therapy and exercise on 64 obese women, ages 20 to 40. One group exercised and received red light therapy treatments, while the control group just exercised. They concluded that red light therapy and exercise together were more effective than just exercise in reducing fat mass. Researchers also observed an increase in skeletal muscle mass. They wrote:

“Our results demonstrated for the first time th at light therapy enhances the physical exercise effects in obese women undergoing weight loss treatment promoting significant changes in inflexibility metabolic profile.” [14]

A recent study published in 2018 also evaluated obese young women and found simi lar results. Some followed an exercise regimen + red light therapy, while the control group just did the exercise. The women who did exercise and red light therapy saw more significant changes in fat mass and insulin variables. Researchers concluded:

“It was demonstrated that exercise training associated with light therapy promotes an improvement in body composition and inflammatory processes. The light therapy group especially presented positive modifications of WNT5 signaling, FGF – 21, and ANP, possible biomarkers associated with browning adiposity processes. This suggests light therapy is applicable in clinical practice to control obesity.” [15]

A placebo – controlled clinical trial in 2015 noted similar improvements with obese women who exercised and were treated with red light therapy. Researchers also concluded red light therapy could control cardiometabolic risk factors in obese populations. [16]

[1] Hamblin M. “Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation” Photochemistry and Photobiology. 2018, 94:199 – 212. 2017 October 31. doi: 10.1111/php.12864

[2] Emília de Abreu Chaves M, Rodrigues de Araújo A, Piancastelli ACC, and Pinotti M. “Effects of low – power light therapy on wound healing: LASER x LED.” An Bras Dermatol. 2014 Jul – Aug; 89(4): 616 – 623.

[3] Hamblin M. “Mechanisms and applications of the anti – inflammatory effects of photobiomodulation”. AIMS Biophys. 2017; 4(3): 337 – 361. doi: 10.3934/biophy.2017.3.337

[4] Brassolatti P, de Andrade ALM, et al. Photobiomodulation on critical bone defects of rat calvaria: a systematic review. Lasers in Medical Science. 2018 Dec;33(9):1841 – 1848.

[5] Pinheiro AL, Gerbi ME. Photoengineering of bone repair processes. Photomedicine and Laser Surgery. 2006 April.

[6] Heo JH, Choi JH, Kim IR, e t al. Combined Treatment with Low – Level Laser and rhBMP – 2 Promotes Differentiation and Mineralization of Osteoblastic Cells under Hypoxic Stress. Tissue Engineering and Regenerative Medicine. 2018 Nov 17;15(6):793 – 801.

[7] Tschon M, Incerti – Parenti S, Cepo llaro S, et al. Photobiomodulation with low – level diode laser promotes osteoblast migration in an in vitro micro wound model. Journal of Biomedical Optics. 2015 Jul;20(7):78002. [8] Avci P, Gupta A, et al. Low – level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Seminars in Cutaneous Medicine and Surgery. Mar 2013; 32(1): 41 – 52. [9] Wunsch A and Matuschka K. A Controlled Trial to Determine the Efficacy of Red and Near – Infrared Light Treatment in Patient Satisfaction, Reduction of Fin e Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase. Photomedicine and Laser Surgery. Feb 2014; 32(2): 93 – 100.

[10] Paolillo FR, Borghi – Silva A, et al. New treatment of cellulite with infrared – LED illumination applied during high – intensity treadmill training. J Cosmet Laser Ther. 2011 Aug;13(4):166 – 71.

[11] Caruso – Davis MK, Guillot TS, Podichetty VK, Mashtalir N, Dhurandhar NV, Dubuisson O, Yu Y. Efficacy of low – level laser therapy for body contouring and spot fat reduction. Obes Surg. 2011. Jun;21(6):722 – 9.

[12] Jackson RF, Dedo DD, Roche GC, et al. Low – level laser therapy as a non – invasive approach for body contouring: a randomized, controlled study. Lasers in Surgery and Medicine. Dec 2009;41(10):99 – 809.

[13] Miranda EF, Tomazoni SS, et al. When is the best moment to apply photobiomodulation therapy (PBMT) when associated to a treadmill endurance – training program? A randomized, triple – blinded, placebo – controlled clinical trial. Lasers in Med Science. 2018 May;33(4):719 – 727.

[14] Sene – Fiorese M, Duarte FO, et al. The potential of phototherapy to reduce body fat, insulin resistance and “metabolic inflexibility” related to obesity in women undergoing weight loss treatment. Lasers Surg Med. 2015 Oct;47(8):634 – 42.

[15] da Silveira Campos RM, Dâmaso AR, et al. The effects of exercise training associated with low – level laser therapy on biomarkers of adipose tissue transdifferentiation in obese women. Lasers in Medical Science. 2018 Aug;33(6):1245 – 1254.

[16] Duarte FO, et al. Can low – level laser therapy (LLLT) associated with an aerobic plus resistance training change the cardiometabolic risk in obese women? A placebo – controlled clinical trial. J Photochem Photobiol B. 2015 Dec;153:103 – 10.

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